The science behind the natural reverse-aging molecule: NMN

In the pursuit of longevity, a powerful natural compound has emerged at the forefront of scientific research: NMN ( β -Nicotinamide mononucleotide).

The science behind the natural reverse-aging molecule: NMN

In the pursuit of longevity, a powerful natural compound has emerged at the forefront of scientific research: NMN (β-Nicotinamide mononucleotide) is not just another supplement. It’s a fundamental building block that your body uses to create NAD+ (Nicotinamide adenine dinucleotide), an essential coenzyme crucial for energy production, metabolism, and DNA repair.

The Age-Related NAD+ Decline

As we age, our natural NAD+ levels experience a sharp decline, potentially by up to 50% in some tissues [1]. This decrease is directly linked to many common signs of aging, including fatigue, cognitive slowdown, and the physical manifestations of cellular wear and tear [1, 2]. When NAD+ levels drop, our cellular engines don't function as efficiently, impacting everything from energy production to cellular repair mechanisms.

NMN: Reactivating Your Cellular Engines

This is where NMN becomes a game-changer. By supplementing with NMN, you help to restore and replenish these vital NAD+ levels, effectively "reactivating" your cellular engines [2, 3]. Studies have shown that oral NMN supplementation can significantly increase blood NAD+ concentrations in middle-aged and older individuals, with dosages ranging from 300 mg to 900 mg daily over 60 days showing statistically significant increases [3, 4].

The Proven Benefits of NMN Supplementation (Supported by Human Studies)

Daily NMN supplementation has been shown to offer a wide range of benefits:

  • Boosts NAD+ levels: Essential for cellular repair and overall vitality. Clinical trials demonstrate NMN's ability to significantly raise NAD+ levels in human blood [3, 4, 5].
  • Improves energy metabolism and endurance: Human studies indicate improvements in physical performance, such as increased walking distance in a 6-minute walk test, particularly at doses of 600 mg and 900 mg daily [3, 4]. Other research suggests NMN may improve aerobic capacity and muscle performance [6].
  • Sharpens memory, focus, and cognitive performance: By supporting brain health, NMN contributes to improved cognitive function [6].
  • Promotes healthy aging and a longer lifespan: While long-term human studies are ongoing, preclinical evidence and initial human reports suggest NMN's potential in mitigating age-related decline and extending healthspan [1, 5, 6].
  • Supports cardiovascular and metabolic function: NMN supplementation has been linked to improvements in insulin sensitivity and a reduction in blood triglyceride levels [1, 6, 7].
  • Rejuvenates skin: Research suggests NMN may contribute to skin health by reducing inflammation and promoting elasticity [6].
  • Improves sleep quality and circadian rhythm: While direct effects on sleep quality require more study, NMN has been observed to reduce overall drowsiness and improve muscle responsiveness [7].

Why Numan's NMN Stands Apart

Numan's NMN is manufactured with the highest standards:

  • 100% Biosynthetic: Our NMN is not derived from plants, eliminating agricultural impurities and fillers.
  • 99% Purity: Each batch is lab-tested to ensure exceptional purity, a critical factor for efficacy and safety [8].
  • Clinically Verified: Our product is supported by data and manufactured in a state-of-the-art GMP factory, with third-party testing for safety and potency. Human studies have generally found NMN supplementation to be safe and well-tolerated at doses up to 900 mg daily and even up to 1,250 mg daily in studies [3, 4, 6, 7].

By choosing Numan, you're embracing the future of science-backed longevity, empowering your body to restore its natural vitality and truly "start from within."




References:

1.    Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner | bioRxiv. Available at: https://www.biorxiv.org/content/10.1101/2024.06.21.599604v1.full-text
2.    The Safety and Anti-Ageing Effects of Nicotinamide Mononucleotide in Human Clinical Trials: An Update - ResearchGate. Available at: https://www.researchgate.net/publication/373304806_The_Safety_and_Anti-Ageing_Effects_of_Nicotinamide_Mononucleotide_in_Human_Clinical_Trials_An_Update
3.    The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial - PubMed. Available at: https://pubmed.ncbi.nlm.nih.gov/36482258/
4.    Towards personalized nicotinamide mononucleotide (NMN) supplementation - medRxiv. Available at: https://www.medrxiv.org/content/10.1101/2024.02.19.24303025v1.full.pdf
5.    Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects - Frontiers. Available at: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.868640/full
6.    NMN (Nicotinamide Mononucleotide): Benefits, Side Effects, and Dosage - Healthline. Available at: https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage
7.    NMN: Benefits, Side Effects And Dosage - Forbes. Available at: https://www.forbes.com/health/supplements/nicotinamide-mononucleotide/
8.    The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7238909/